21 4月 assignment代写：速尿的作用
地高辛的替代品是速尿，可用于治疗充血性心力衰竭、肝硬化和肾病综合征相关的肝病。速尿被认为是利尿剂，它减少重组GABA (a)受体介导的电流，也阻止癫痫样放电。呋塞米的作用机理特别重要，因为它不影响60微m异古瓦辛以下的电流。速尿作为一种环型利尿剂，作为一种具有明显囊性纤维化跨膜电导(CFTR)动力学特征的开放通道阻滞剂效果最佳(George and Craig 335 -387)。对患者进行的初步研究表明，呋塞米以非常快的速度、中等的速度阻断特定的CFTR通道。速尿是一种磺胺衍生物和环状利尿剂。该药物重新吸收钠和氯进入上升和厚环亨利导致损失钠水和氯在尿液。
The alternative to Digoxin can be in the form of Furosemide which can be used for the treatment of congestive heart failure, liver cirrhosis and nephrotic syndrome related liver diseases. Furosemide is considered as a diuretic, and it decreases recombinant GABA (A) receptor-mediated currents and also blocks epileptiform discharges. The mechanism of Furosemide is particularly important as it does not affect currents under 60 microM isoguvacine. Furosemide as a loop diuretic operates best as an open channel blocker with the distinct kinetics of cystic fibrosis transmembrane conductance (CFTR) (George and Craig 355-387).The primary research conducted over patients show that Furosemide blocked particular CFTR channels in a very fast mode with moderate speed.Furosemide is a sulfonamide derivative and a loop diuretic. The drug reabsorbs sodium and chloride into the ascending and thick loop of Henle resulting in losses of sodium water and chloride in urine.
Furosemide can be administered with atropine which will not cause the kind of interactions normally found in Digoxin toxicity as atropine sulphate can alter severe sinus bradycardia. Furosemide can also be administered with magnesium sulfate as magnesium sulfate has the potential termination advantage of dysrhythmias (Richard 275-305). Thus, the drug and its chemical composition can be helpful in treatment. Mifepristone: This drug is prescribed for the severe and the infectious fatal bleeding which rarely occurs during an abortion. The mechanism or the action which is involved consists of the intracellular receptors with consisting of antagonized hormones that contain the progesterone and the glucocorticosteroids. The major action consists of the high binding affinity of the receptors and the interaction of the Phenylaminodimethyl group in the 11 affinities to the receptors. For this reason, the importance of this drug is illustrated with the mechanism and thereby it helps to avoid unintended pregnancy (Karasu 871-880).